Results
| PMID | 23237776 |
| Gene Name | IL10 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | IL-10 -592 A/C, IL-10 -1082 A/G, IL-10 -819 T/C |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Gene. 2013 Feb 15;515(1):49-55. doi: 10.1016/j.gene.2012.11.037. Epub 2012 Dec Fan, Wei| Li, Shangwei| Chen, Qiong| Huang, Zhongying| Ma, Qianhong| Xiao, Zhun Center of Reproductive Medicine, The West China Second University Hospital, Sichuan University, Sichuan, PR China. fw215@163.com To investigate the influence of the interleukin-10 gene promoter polymorphisms on the susceptibility of endometriosis, we examined the association by performing a meta-analysis. The PubMed, Embase, HuGE Navigator and CNKI were searched to identify eligible studies. We then conducted a meta-analysis to examine the association between interleukin-10 gene promoter polymorphisms and endometriosis. Eight case-control studies which examined the association between the IL-10 gene promoter polymorphisms and the susceptibility to endometriosis were finally included in the meta-analysis. Meta-analysis of the IL-10 -592 A/C polymorphisms showed a significant increased risk of endometriosis in the overall and Asian population in all genetic models and allele contrast. However, meta-analysis of the IL-10 -1082 A/G and IL-10 -819 T/C polymorphisms showed no association with endometriosis in all genetic models and allele contrast in the overall and Asian population samples. In addition, there was not a significant association between the IL-10 -592 A/C gene promoter polymorphisms with the severity of endometriosis. In conclusion, this meta-analysis suggests that the IL-10 -592 A/C polymorphisms conferred susceptibility to endometriosis. However, no associations were found between the IL-10 -1082 A/G and -819 T/C polymorphisms and susceptibility to endometriosis. Further studies are required to elucidate these associations more clearly. Mesh Terms: Alleles| Endometriosis/*genetics/pathology| Female| *Genetic Predisposition to Disease| Genotype| Humans| Interleukin-10/*genetics| Odds Ratio| *Polymorphism, Single Nucleotide| *Promoter Regions, Genetic| Publication Bias|DA 2013/03/19 06:00 |
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